Introduction
The INICET May 2025, conducted by AIIMS for postgraduate medical admissions, reinforced its reputation as a rigorous, application-driven examination. With 200 single-best-answer MCQs spanning all 19 subjects, this session not only tested factual recall but demanded diagnostic acumen and integrated clinical reasoning.
This comprehensive analysis breaks down each subject systematically — highlighting key question trends, dominant topics, and essential takeaways. Whether you’re preparing for INICET November 2025 or beyond, this resource serves as both a strategic roadmap and a performance reflection tool.
Overview of Exam Pattern and Trends
Difficulty Level: Moderate to Difficult
Question Format Distribution:
Clinical vignettes: ~60–65%
One-liners: ~25%
Image-based MCQs: ~10%
- Overall Trend: Strong emphasis on vertical and horizontal integration of basic sciences and clinical medicine
The exam rewarded those who could interlink pathology, pharmacology, physiology, and medicine — often in a single question stem.
Subject-Wise Analysis
1. Pharmacology
Dominant Areas:
- Mechanisms of action (e.g., phenoldopam, bempedoic acid)
- Antimicrobials, cardiovascular drugs
- Adverse effects (QT prolongation, cholestasis)
- Drug interactions and safety profiles
Trend:
The focus was on conceptual pharmacology, moving beyond mere recall. Integration with microbiology and medicine was evident. For instance, case-based drug choices in infections and CNS disorders were highlighted.
Difficulty: Moderate to High
High-Yield Tip: Master drug mechanisms and their clinical implications rather than memorizing drug lists.
2. Biochemistry
Dominant Areas:
- Genetic diagnostics (Next-Generation Sequencing, surface plasmon resonance)
- Inborn errors of metabolism
- BRCA mutation profiling and Warburg effect
- Lysosomal storage diseases
Trend:
Biochemistry questions were heavily applied, especially in the context of cancer biology and diagnostics. Multiple MCQs required knowledge of diagnostic technologies and their appropriate use.
Difficulty: High
High-Yield Tip: Focus on molecular diagnostics and cancer genetics; these are increasingly recurrent themes.
3. General Medicine
Dominant Areas:
- Cardiology (pulsus alternans, HFpEF)
- Neurology (seizure workup, GBS)
- Infectious diseases (cryptococcal infections, TB)
- Respiratory and renal integration
Trend:
Medicine questions emphasized case-based reasoning. Concepts like preserved EF heart failure, cardiac tamponade recognition, and interpretation of PFTs appeared in realistic clinical settings.
Difficulty: Moderate
High-Yield Tip: Strengthen your understanding of core clinical decision-making, especially for high-burden conditions.
4. Preventive and Social Medicine (PSM)
Dominant Areas:
- Biostatistics (t-tests, dispersion)
- RMNCH+A strategy
- Epidemiological surveillance (e.g., Kumbh Mela)
- National programs (NACO, RNTCP)
Trend:
The questions leaned toward applied public health, combining statistics with real-world programmatic knowledge. Definitions (e.g., dependency ratio, blindness) and case scenarios were common.
Difficulty: Moderate
High-Yield Tip: Don’t neglect numerical epidemiology and program-based questions. They offer high scoring potential with consistent patterns.
5. Forensic Medicine
Dominant Areas:
- Indian BNS Act (Section 116)
- MTP consent rules
- Tests for poisoning (e.g., silver nitrate)
- Grievous vs. simple injury classification
Trend:
This session’s forensic section focused on legal interpretation and new law updates, like BNS replacing IPC. Questions demanded clarity on consent, age of marriage, and grievous hurt classification.
Difficulty: Moderate
High-Yield Tip: Be thorough with BNS updates and real-life legal applications in medicolegal contexts.
6. Psychiatry
Dominant Areas:
- Depression and psychosis (e.g., autistic thinking)
- Ketamine as a rapid-acting antidepressant
- Valproate teratogenicity
- Withdrawal syndromes
Trend:
Psychiatry MCQs tested clinical therapeutics and DSM-based symptomatology. Integration with pharmacology and obstetrics (e.g., drug safety in pregnancy) was prominent.
Difficulty: Low to Moderate
High-Yield Tip: Focus on clinical decision-making and drug contraindications, especially in special populations.
7. Pediatrics
Dominant Areas:
- Neonatal RDS and GERD
- Pediatric nephritis (SLE-related)
- Developmental milestones
- Thrombocytopenia and ITP
Trend:
This section featured clinical scenarios, especially for neonates and infants. Candidates were tested on decision-making in conditions like GERD, SLE-induced nephritis, and inborn errors such as Niemann-Pick disease.
Difficulty: Moderate
High-Yield Tip: Focus on practical pediatrics — neonatal care, growth, and emergency management.
8. Radiology
Dominant Areas:
- Hallervorden-Spatz (Eye of the tiger sign)
- Sacral fractures (Honda sign)
- Neurocysticercosis (Scolex dot sign)
- Urolithiasis imaging modalities
Trend:
Although image-based questions were fewer this time, the exam still prioritized pattern recognition and diagnostic tool selection. Functional imaging like SPECT and Sestamibi were highlighted.
Difficulty: Moderate
High-Yield Tip: Memorize radiologic signs and know when to choose CT, MRI, or functional imaging in clinical cases.
9. Surgery
Dominant Areas:
- Breast cancer staging (T4 lesion)
- Surgical procedures (Z-plasty, duodenal switch)
- Scoring systems (MANTRELS for appendicitis)
- Bone fixation (PFN)
Trend:
Surgery was rich in application-based questions. Concepts such as Calot’s triangle anatomy, definitive management of fractures, and breast tumor classification featured prominently.
Difficulty: High
High-Yield Tip: Understand anatomical correlations and surgical principles, not just procedural names.
10. Microbiology
Dominant Areas:
- Enterobius (D-shaped ova)
- Satellite phenomenon (Haemophilus influenzae)
- Dimorphic fungi, Kanagawa phenomenon
- Stains for diagnostic clarity
Trend:
There was a noticeable tilt toward infection-focused MCQs, with strong emphasis on diagnostic microbiology and pathogen identification, especially parasitology and fungal markers.
Difficulty: Easy to Moderate
High-Yield Tip: Revise PYQs and laboratory diagnostic techniques, especially for rare pathogens and characteristic signs.
11. Orthopedics
Dominant Areas:
- Bone tumors (Codman’s triangle, sunburst)
- Fracture management
- Pediatric skeletal trauma
- Immobilization principles
Trend:
Orthopedic questions required visual interpretation and decision-making. The exam tested empirical treatment (e.g., scaphoid cast even with normal X-ray) and understanding of age-related fracture types.
Difficulty: High
High-Yield Tip: Know radiographic signs of tumors and the principles of splinting and emergency orthopedics.
12. Ophthalmology
Dominant Areas:
- INO diagnosis
- Retinal layers on OCT
- Cranial nerve supply of orbit
- Amblyopia and occlusion therapy
Trend:
This subject focused on neuro-ophthalmologic correlation and the use of imaging (like OCT) in diagnostics. Functional vision preservation and interpretation of visual pathways were central.
Difficulty: Moderate
High-Yield Tip: Revise cranial nerve functions and layers of retina as they frequently appear in integrated MCQs.
13. Dermatology
Dominant Areas:
- STDs (secondary syphilis, herpes)
- Scabies in infants
- Topical steroid side effects
- Skin histology
Trend:
MCQs demanded clinical recognition of skin lesions, and the diagnostic tool was often VDRL or Gram stain. Histological aspects like acellular layers were tested.
Difficulty: Low to Moderate
High-Yield Tip: Focus on infectious dermatoses, histopath clues, and adverse effects of treatment.
14. Anatomy
Dominant Areas:
- Cross-sectional and surgical anatomy
- Nerve supply of head & neck
- Ulnar nerve exceptions
- Piriform fossa, piriformis action
Trend:
Anatomy was visually demanding and clinically relevant. The exam tested high-yield surgical landmarks and neurovascular pathways, including questions on imaging and nerve supply exceptions.
Difficulty: High
High-Yield Tip: Focus on 3D visualization, nerve innervations, and image-based anatomy, especially in relation to surgery and ENT.
15. Physiology
Dominant Areas:
- Bezold-Jarisch reflex
- Tight junctions and transport proteins
- ADH actions and apical membrane transport
- Hippocampal memory roles
Trend:
Physiology questions focused on clinical integration, with many linking regulatory mechanisms to disease states. There was emphasis on endocrine physiology and homeostatic feedback systems.
Difficulty: Moderate
High-Yield Tip: Master regulatory loops and hormone action pathways, especially where they connect to medicine (e.g., SIADH, diabetes insipidus).
16. Pathology
Dominant Areas:
- Tumor markers (e.g., Call-Exner bodies)
- Pyroptosis (Caspase 1)
- Inherited bleeding disorders (von Willebrand)
- Cancer histology and apoptosis pathways
Trend:
Pathology leaned toward molecular pathogenesis, requiring understanding of mechanisms behind cell death and tumor marker significance.
Difficulty: Moderate to High
High-Yield Tip: Focus on morphological hallmarks and immuno-pathological markers, especially for ovarian and hematologic tumors.
17. Obstetrics & Gynecology
Dominant Areas:
- MTP Act amendments
- Pap smear procedural steps
- Coffee bean nuclei (Granulosa cell tumors)
- Uterotonics and PPH management
Trend:
Fewer questions than usual, but challenging and practical. The legal framework of termination and choice of appropriate therapy (e.g., oxytocics) were key focus points.
Difficulty: High
High-Yield Tip: Keep updated with legislative changes and WHO guidelines, especially concerning MTP, contraceptives, and labor emergencies.
18. ENT
Dominant Areas:
- BPPV and vestibular signs
- Cochlear implants
- Contraindicated biopsies in JNA
- Congenital hearing loss
Trend:
ENT tested clinical red flags and procedural knowledge. Most MCQs had a practical slant — e.g., avoiding biopsy in vascular tumors.
Difficulty: Moderate
High-Yield Tip: Know nerve pathways, hearing devices, and classic ENT emergencies and contraindications.
19. Anesthesia
Dominant Areas:
- Thiopentone redistribution
- Neostigmine use for vecuronium reversal
- Lumbar puncture complications
- Spinal anesthesia contraindications
Trend:
Focused on perioperative decision-making, with emphasis on mechanisms and complications. Candidates needed to differentiate between similar-acting drugs and interpret effects based on pharmacokinetics.
Difficulty: Moderate
High-Yield Tip: Be confident in drug usage protocols and safety profiles, especially for commonly used agents in surgical settings.
Strategy Guide for INICET November 2025
The May 2025 session clearly demonstrated that INICET is no longer a factual recall exam — it is a clinical reasoning battleground. To excel, aspirants must shift their preparation style accordingly.
Here’s a step-by-step strategy:
1. Master Cross-Subject Integration
Expect questions that demand links between:
- Pathology + Surgery (tumor staging + clinical decision)
- Pharmacology + Medicine (drug mechanisms in HFpEF)
- Physiology + Medicine (reflexes and autonomic regulation)
- Biochemistry + Oncology (BRCA, metabolism in cancer)
Action Plan: Build flowcharts and concept maps that cross subject boundaries.
2. Prioritize Conceptual Clarity Over Rote Learning
One-liners still appear, but 70% of the paper is clinical. You must:
- Eliminate wrong options via logic
- Justify your choices clinically
- Understand mechanisms, not just names
Action Plan: Practice with clinical vignettes and “why not the others” explanations.
3. Stay Updated With Guidelines and Legal Revisions
Questions from:
- MTP Act Amendments
- BNS sections (e.g., 116)
- WHO/NACO protocols for HIV, TB, RMNCH+A
Action Plan: Keep a summary file of recent Indian and global health updates.
4. Reinforce Biochemistry, PSM, and Forensic Medicine
These were unexpectedly high-yield:
- Biochem: Cancer diagnostics, enzyme-linked disorders
- PSM: Applied epidemiology, biostatistics
- Forensic: Legal definitions, updated BNS terminology
Action Plan: Don’t marginalize short subjects; many offer easy scoring.
5. Revise Through Past Recall MCQs
~30% of questions were modifications of previous years:
- VDRL for syphilis
- Satellite phenomenon
- Warburg effect
- Caspase-linked cell death
Action Plan: Create a rapid revision bank of previously asked questions.
6. Practice Full-Length Tests With Time Pressure
200 MCQs in 180 minutes requires:
- Fast clinical reasoning
- Efficient elimination
- Prioritization of easier questions first
Action Plan: Attempt weekly INICET-style mocks with subject-mix format.
Final Thoughts: Lessons from INICET May 2025
- Think clinically.
- Revise intelligently.
- Apply knowledge, don’t just recall it.
This paper reinforced AIIMS’ long-standing vision: to select thinking doctors, not memorizers.
What’s Next?
Want to take your prep to the next level?
✅ Get the full 200-question PDF with answers
✅ Download subject-wise cheat sheets
✅ Join our free WhatsApp Channel for daily recall updates
Tap here: Join the Med Exams Prep WhatsApp Channel
Write to us at: info@medexamsprep.com